Lichen planus
is a rash characterized by intensely itchy polygonal papules with a violaceous
hue involving the skin and less commonly the mucosae, hair, and nails.
It affects
all age groups but is most common between the ages of 30 and 60. Children and
infants are not commonly affected. There are no gender or racial
predispositions.
Etiology
·
The cause is unknown but an immune
pathogenesis is suspected as there is an association with some autoimmune
diseases such as myasthenia gravis, and with thymoma and graft-versus-host
disease.
·
Rashes with clinical and histological
features of lichen planus can occur in chronic active hepatitis, hepatitis B
and C infections.
·
Patients taking drugs, the most
common culprits being gold and other heavy metals, sulphonamides,
penicillamine, antimalarials, antituberculos drugs, and thiazide diuretics,
also develop rashes.
·
They also occur in those handling
color developers.
Pathogenesis
There is
hyperkeratosis, a prominent granular layer, basal cell degeneration and a heavy
T lymphocyte infiltration in upper dermis. Degenerating basal cells may form
colloid (apoptotic) bodies. The T cell-basal cell interaction leaves a
‘sawtooth’ dermo-epidermal junction. The picture suggests an immune reaction to
an unknown epidermal antigen.
Clinical
features
Distribution
site:
·
Wrists (volar/flexor aspect of wrist)
·
Ankles
·
Oral mucous membrane
·
Shins
·
Lower back and genitalia
Signs and
symptoms include:
·
Shiny, violaceous flat-topped papules
and plaques
·
Purplish papules, purplish nodules on
skin at sites of friction
·
Sore or painful or asymptomatic
·
Polygonal
·
Severe pruritus. The patients rub
rather than scratch, so that excoriations are uncommon.
·
Fine lacy white markings on top of
papules known as Wickham striae. These striae are most prominent in the oral
mucosa.
·
Scratching and trauma induce new
lesions (Koebner phenomenon)
·
On the scalp it can cause cicatricial
alopecia
Nail lichen
planus
·
Nail involvement is seen in 10% of
patients
·
Longitudinal ridging of the nail
plate, with nail plate thinning
·
Scarring of the matrix that causes
pterygium (a wing-like permanent nail dystrophy) and anonychia.
·
Rarely the papules split the nails
and give the ‘tented nail’ or ‘pup tent sign’.
Oral mucosa
lichen planus
·
Common sites are buccal mucosa,
tongue, gingiva, lips
·
White striae in mouth present on a
spectrum ranging from a mild, white, reticulate eruption of the mucosa to a severe,
erosive stomatitis.
·
Ulcers to severe erosive stomatitis,
erosive gingivitis.
·
White streaks, often forming a
lacework, on the buccal mucosa are highly characteristic.
·
Erosive stomatitis may persist for
years and may be linked to an increased risk of oral squamous cell carcinoma.
·
Occasionally lichen planus lesion
from oral mucosa extend to larynx/esophagus, results in dysphagia and formation
of benign strictures.
·
In young men lichen planus are
restricted to genitalia and/or mouth.
·
In female erosive lichen planus of
the genitalia with desquamative gingivitis.
Homeopathy
medicines
Homoeopathy today is a
growing system and is being practiced all over the world. Its strength lies in
its evident effectiveness as it takes a holistic approach towards the sick
individual through promotion of inner balance at mental, emotional, spiritual
and physical levels. When Lichen planus
is concerned there are many effective medicines are available in
Homoeopathy, but the selection depends upon the individuality of the patient,
considering the mental and physical symptoms.
Agaricus muscarius
Papular,
pustular, and edematous lesions. Eruption of small pimples like with red areola
and violent itching and burning. Sensation in various parts as if ice cold
needles were piercing the skin.
Anthrakokali
Papular
eruptions on hands and feet. Intense itching.
Antimonium
crudum
Scaly,
pustular eruption with burning and itching, worse at night. Rough scaling skin
with horny patches. Great tenderness in horny patches. Thick, hard,
honey-colored scabs. Itching when warm in bed. Dry skin. Itching of scalp and
falling out of hair. Tongue coated thick white, as if whitewashed. The edges
may be red and sore. Sensitive to cold bathing. Nails discolored and deformed.
Arsenicum
album
Itching,
burning, swelling; edema, eruption popular, dry, rough, scaly; worse cold and
scratching. Malignant pustules. Ulcers with raised and hard edges, surrounded
by a red and shinning crown; with the bottoms like hard, or of a blackish-blue,
with burning pains or shooting, principally when the parts affected become
cold. Great anguish and restlessness. Changes places continually. Fear of death.
Arsenicum
iodatum
Dry, scaly,
and itching lesions. Marked exfoliation of skin in large scales, leaving a raw
exuding surface beneath.
Borax
For oral
lichen planus. Ulcers inside the cheeks and on tongue. Mouth hot and tender.
Bitter taste in the mouth on eating or on swallowing the saliva. Dry cracked or
puffy indented tongue. Ulcers, bleed on eating or by touch.
Dulcamara
Pruritus,
always worse in cold, wet weather. Vesicular eruptions. Humid eruptions on
face, genitals, and hands. Thick brown-yellowish crusts, bleeding when
scratched. Warts, large, smooth, on face and palmar surface of hands.
Juglans
cineraria Q
Eruption
resembling eczema simplex on upper chest, with itching pricking when heated by
over-exertion. Pustules on thighs, hips, and nates, with itching and burning, a
few pustules on body, face, and arms. Itching in spots, now here, now there, on
head, neck, and shoulders, with pricking, burning and redness. Itching on arms,
better from scratching.
Kali arsenicosum
Intolerable
itching, worse from undressing. Dry, scaly, wilted skin. Itching worse from warmth. Numerous small
nodules under skin.
Kali
bichromicum
Papular
eruption, with burning pains. Hands become covered with deep, stinging
cicatrice. Ulcer with punched-out edges, with tendency to penetrate and
tenacious exudation.
Ledum
palustre
Eruption of
small pimple like red millet seed over the body. Intense itching of feet and
ankles, worse scratching and warmth of bed. Eruption only on covered part.
Edematous swelling.
Mercurius sol
For oral
lichen planus. Irregular ulcers inside the cheeks. The edges are not well
defined. Unhealthy and dirty appearance of cheek. Profuse salivation. Offensive
odor from the mouth. Metallic taste in the mouth. Increased thirst for water.
Plantago
major
For oral
lichen planus. Swelling of cheeks. Profuse flow of saliva. Dirty taste. Tongue
coated white, with dirty, putrid, clammy taste. Breath putrid.
Sulphur
Dry, scaly,
unhealthy skin; every little injury suppurates. Itching, burning; worse
scratching and washing. Dirty, filthy people, prone to skin affections. Very
red lips and face. Skin affections after local medication. Pruritus, especially
from warmth, in evening, often recurs in spring-time, in damp weather. Aversion
to being washed, always worse after bath. Craving for sweets.
Sulphur
iodatum
Lichen
planus. Arms covered with itching rash. Hair feels as if erect. Papular eruption on face. Obstinate skin
affections; painless enlargement of glands, and infiltration of tissues with
thickening and induration after inflammation.
Thuja
occidentalis
Dry skin with
brown spots. Brown spots on hands and arms. Very sensitive skin to touch. Sweetish
and strong perspiration. Lichen planus of pigmented variety.
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